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Neonatal thyrotoxicosis with maternal hypothyroidism

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Neonatal Graves’ is uncommon, but a potentially fatal condition caused by transplacental transfer of thyroid stimulating immunoglobulin (TSI). It is seen in 1%–5% of infants born to a mother with… Click to show full abstract

Neonatal Graves’ is uncommon, but a potentially fatal condition caused by transplacental transfer of thyroid stimulating immunoglobulin (TSI). It is seen in 1%–5% of infants born to a mother with Graves’ disease. Here, we report a unique case of transient neonatal thyrotoxicosis with positive TSI in a premature neonate born to the mother with primary hypothyroidism. A short course of antithyroid drug treatment leads to significant clinical and biochemical improvement followed by complete recovery.

Keywords: maternal hypothyroidism; thyrotoxicosis maternal; thyrotoxicosis; neonatal thyrotoxicosis

Journal Title: BMJ Case Reports
Year Published: 2022

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