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IgG4-positive Hashimoto thyroiditis and its association with IgG4-related sclerosing disease

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A woman in her 50s was referred with suspected thyroid malignancy and underwent total thyroidectomy. Immunohistochemical analysis revealed IgG4-positive Hashimoto’s thyroiditis. IgG4-related thyroid disease is poorly understood, and thought to… Click to show full abstract

A woman in her 50s was referred with suspected thyroid malignancy and underwent total thyroidectomy. Immunohistochemical analysis revealed IgG4-positive Hashimoto’s thyroiditis. IgG4-related thyroid disease is poorly understood, and thought to encompass various entities including IgG4-positive Hashimoto’s thyroiditis, Fibrosing Variant of Hashimoto’s thyroiditis, Reidel’s thyroiditis and Graves’ disease with elevated IgG4 levels. Furthermore, it may be associated with a systemic fibrosing condition called ‘IgG4-related sclerosing disease’. The clinical significance of IgG4-positive thyroid disease, however, remains unclear.

Keywords: igg4 positive; igg4; hashimoto thyroiditis; disease; thyroiditis

Journal Title: BMJ Case Reports
Year Published: 2022

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