LAUSR

Aims To investigate the relationship between choriocapillaris (CC) blood perfusion and the severity of diabetic retinopathy (DR) using swept-source optical coherence tomography angiography (SS-OCTA). Methods Type 2 diabetes mellitus in the Guangzhou was recruited. DR was graded according to the standardised seven-field colour retinal images adhering to the ETDRS scale. CC perfusion was quantified by evaluating the flow deficit (FD) density, FD number and FD size using SS-OCTA. Multivariable linear regressions were used to evaluate the correlation between CC FD metrics and DR severity. Results A total of 1692 patients (eyes) were included in the final analysis. Participants with DR had a significantly higher FD density than the NDR group, with the differences of 1.61% (95% CI 1.04 to 2.18; p<0.001) among mild non-proliferative DR (NPDR) patients, 2.23% (95% CI 1.76 to 2.70; p<0.001) among moderate NPDR patients and 3.31% (95% CI 2.27 to 4.36; p<0.001) among severe DR than NDR patients after adjusting for confounding factors. Similarly, the higher FD number and size were also correlated with severer degree of DR (all p<0.05). Furthermore, the addition of FD density to conventional risk factors significantly improved the performance for discriminating DR from NDR patients (AUC 0. 829, 95% CI 0. 804 to 0. 855; p<0.001). Conclusion Quantitative FD density, number and size assessed by using SS-OCTA were independently correlated with the severity of DR. The assessment of the CC perfusion metrics in the macula may be a sensitive biomarker of DR changes.