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The ability of tumour cells to escape the surveillance and elimination by the immune system represents one of the hallmarks of cancer.1 2 This concept of immune control against cancer… Click to show full abstract
The ability of tumour cells to escape the surveillance and elimination by the immune system represents one of the hallmarks of cancer.1 2 This concept of immune control against cancer development, recognised more than 60 years ago by Paul Ehrlich, has recently led to the development of novel different treatment approaches (ie, cancer immunotherapy) aiming to reinvigorate the capability of the immune system to recognise and eliminate tumour cells.3 For this purpose, while the use of tumour antigenic material as a cancer vaccine has not proven to be particularly successful so far,4 the advent of therapies able to inactivate inhibitory immune receptors (ie, immune checkpoints) leading to a subsequent increased anti-tumour response …
Journal Title: ESMO Open
Year Published: 2019
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