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Immature neutrophils bring anti-PD-1 therapy in NASH-HCC to maturity

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immune suppression in the vicinity of tumour cells. Combinatorial treatment of anti- CXCR2 and anti- PD- 1 in NASH- HCC mouse models led to a recruitment of immature neutrophils from… Click to show full abstract

immune suppression in the vicinity of tumour cells. Combinatorial treatment of anti- CXCR2 and anti- PD- 1 in NASH- HCC mouse models led to a recruitment of immature neutrophils from the bone marrow into the tumour, subsequently promoting efficient priming of tumour- specific CD8 T cells by activated XCR1 + cDC1. XCR1, X- C motif chemokine receptor 1; dendritic cells; CXCR2, CXC chemokine 2;

Keywords: bring anti; nash hcc; immature neutrophils; neutrophils bring

Journal Title: Gut
Year Published: 2022

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