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Each year, the Heart editorial team selects the most meritorious research paper from the preceding year to receive the Heart Best Research Paper Award. Our initial considerations are the number of citations, number of readers and Altmetric score for each paper. Then the editorial team selects the winner and finalists based on the relevance of the clinical question addressed by the research, the quality of the research study design and data presentation, and the potential longterm impact of the research findings. Among the many outstanding research papers in Heart published in 2021, we selected one winner and two finalists for the 2022 Heart Best Paper Award. We sincerely congratulate the first author and the entire research team for each of these publications (table 1). In this article, the winner and finalists provided their professional background and summarised the research goals and the key findings of their studies.