LAUSR

Introduction/Background Removal of the uterus, the target organ for ovarian hormones, causes disorders in neuroendocrine relationships of the hypothalamic-pituitary-gonadal axis. Long-term effects of hysterectomy (HE) in the subsequent malignant transformation of the ovaries are still poorly studied. Our aim was to study some systemic and local neuroendocrine parameters in women with ovarian cancer (OC) developed after HE. Methodology The study included 98 menopausal women with OC, mean age 61.5±3.6: group 1 - OC after HE, group 2 - primary OC; controls - patients with intact ovaries operated on for hysteromyoma. Standard ELISA test systems were used to determine the blood levels of serotonin (5HT), LH, FSH, cortisol (C) and estradiol (E2), and levels of 5HT, 5-HIAA, histamine (H) and activity of MAO-A and DAO in tumor and intact ovarian tissues. All patients gave their voluntary informed consent for the study. Results Blood levels of 5HT in group 1 were 2.2 times lower than the norm, FSH and LH - 2.3 and 2.4 times lower, while in group 2 - 2, 1.3 and 1.8 times higher, respectively. Blood levels of E2 in group 1 were similar to the norm, C - 1.6 times higher. In group 2, C in the blood was similar to the norm in 71% cases and exceeded it by 2.2 times in 29%; E2 was 1.6 times lower. In groups 1 and 2, compared to controls, tissue levels of 5HT were 3.5 and 1.5 times lower, respectively, 5-HIAA 1.6 times lower than the norm, MAO-A activity 2.5 times higher. In both groups, H was lower than in controls, DAO activity in group 1 was decreased by 2.2 times, and in group 2 increased by 3.5 times. Conclusion Development of OC in preserved ovaries after HE, unlike primary OC, is not associated with the pituitary stimulation and is more ‘acquired’ than ‘endogenous’. Disclosure Nothing to disclose.