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Multiple attempts at fertility preservation in atypical endometrial hyperplasia and early endometrial cancer

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CASE PRESENTATION A 40yearold woman with a history of uterine atypical hyperplasia in 2010 was treated with oral progestins for 6 months with complete response. She had no further followup… Click to show full abstract

CASE PRESENTATION A 40yearold woman with a history of uterine atypical hyperplasia in 2010 was treated with oral progestins for 6 months with complete response. She had no further followup until March 2018 when she was referred to the British Hospital of Buenos Aires because during in vitro fertility treatment she was found to have a relapse of atypical endometrial hyperplasia. In 2018 a new fertility preservation attempt was done and an intrauterine device (Mirena) was used until June 2019. At that point the patient had a complete pathologic response and the intrauterine device was removed in order to proceed with fertility treatment. An evaluation every 3 months was planned in case she did not get pregnant. In 2020, because of the COVID19 pandemic, the patient did not have any fertility treatment or followup. She returned in January 2021, referred by the fertility clinic, requesting endometrial sampling before starting the in vitro fertilization treatment and hysteroscopicguided biopsy was performed. DR TOSCANO We received fragments of endometrial mucosa that focally exhibit an irregular proliferation of backtoback glands, with epithelial pseudostratification with atypia, consistent with atypical hyperplasia (Figure 1).

Keywords: fertility; hyperplasia; fertility preservation; endometrial hyperplasia; treatment; atypical endometrial

Journal Title: International Journal of Gynecological Cancer
Year Published: 2022

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