LAUSR

Lynch syndrome results in a significantly increased lifetime risk for several malignancies, including up to 60% risk for colorectal and endometrial cancer. Consensus guidelines recommend screening with colonoscopy every 1–2 years, beginning at age 20–25, and endometrial biopsy every 1–2 years, beginning at age 30–35 years. Colonoscopy is routinely performed under sedation while endometrial biopsy is performed as an office procedure without anesthesia. Office endometrial biopsy requires an additional medical visit and patients often report significant pain, both of which can hinder successful completion of the procedure. Previous groups have suggested that, as colon and endometrial cancers share similar intervals for recommended screening, it is reasonable to offer the tests concurrently under sedation; they found that this approach was feasible, acceptable and improved screening adherence. However, most patients with Lynch syndrome do not have access to this patientcentered approach because few centers offer the combined procedure. Here we report on our experience of launching a program of combined gastrointestinal and endometrial cancer screening for patients with Lynch syndrome. Our goal was that other centers caring for patients with Lynch syndrome would consider creating similar programs.