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NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen… Click to show full abstract
NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.
Keywords:
month nkx3;
gene month;
pathology;
histopathology
Journal Title: Journal of Clinical Pathology
Year Published: 2022
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Journal Title: Journal of Clinical Pathology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!