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Ren Z, et al. J NeuroIntervent Surg Month 2021 Vol 0 Selection criteria for large core trials: rationale for the ANGELASPECT study design Zeguang Ren, Xiaochuan Huo, Gaoting Ma , Xu Tong , Jay Kumar, Elliot Pressman , Wenhuo Chen, Guangxiong Yuan, Alvin YiChou Wang, Ming Wei, Jiangang Zhang, Guangxian Nan, Qiyi Zhu, Yajie Liu, Liyong Zhang, Weigen Song, Zhiming Zhou, Guoqing Wang, Tianxiao Li, Jun Luo, En Wang, Wentong Ling, Dongsheng Ju, Cunfeng Song, ShuDong Liu, Liqiang Gui, Tong Li, Yan Liu, Junfeng Zhao, Zaiyu Guo, Hongbo Zheng, Yaxuan Sun, Na Xu, Yong Jun Wang, Zhongrong Miao, on behalf of ANGELASPECT Investigators and ANGELASPECT Steering Committee