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Synthesis, characterization, and anticancer properties of iminophosphineplatinum(II) complexes containing boronate esters

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Three new iminophosphines containing pinacol-derived boronate esters have been prepared and ligated to dichloridoplatinum(II) fragments. All compounds have been characterized fully, including an X-ray diffraction study carried out for the… Click to show full abstract

Three new iminophosphines containing pinacol-derived boronate esters have been prepared and ligated to dichloridoplatinum(II) fragments. All compounds have been characterized fully, including an X-ray diffraction study carried out for the platinum complex 8, which is derived from 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. These three new platinum complexes, along with the non-boron containing control, have been examined for their initial cytotoxic properties against two glioma cell lines using the MTT method.

Keywords: iminophosphineplatinum complexes; characterization anticancer; boronate esters; anticancer properties; properties iminophosphineplatinum; synthesis characterization

Journal Title: Canadian Journal of Chemistry
Year Published: 2017

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