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Assessing the feasibility and stability of uracil base flipping in RNA–small molecule complexes using molecular dynamics simulations

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Small molecules can be used to target RNAs that mediate disease. A fundamental understanding of binding interactions between RNA and small molecules and the structure of their complexes will furthe... Click to show full abstract

Small molecules can be used to target RNAs that mediate disease. A fundamental understanding of binding interactions between RNA and small molecules and the structure of their complexes will furthe...

Keywords: feasibility stability; uracil base; base flipping; rna small; assessing feasibility; stability uracil

Journal Title: Canadian Journal of Chemistry
Year Published: 2020

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