LAUSR

Medicinal properties of curcumin are widely published. Previously researchers used curcuminoid mixture comprising three chemical forms out of which, the highest quantity is the most active molecule - dimethoxy curcumin (DMC). Reduced bioavailability, poor aqueous solubility and quick hydrolytic degradation of DMC have projected challenges limiting its therapeutic value. However, selective conjugation of DMC with human serum albumin (HSA) enhances drug stability and solubility by several folds. Studies using animal models demonstrated potential anti-cancer/anti-inflammatory effects of DMCHSA; both studies showed results of local administration in peritoneal cavity and rabbit knee joint. DMC has prospects as an intravenous therapeutic agent because carrier is HSA. However, before in vivo testing, important preclinical data required are toxicological safety and bioavailability of soluble forms of DMC. This study evaluated absorption, distribution, metabolism and excretion (ADME) of DMCHSA. Imaging technology and molecular analysis proved bio-distribution. Study also assessed pharmacological safety of DMCHSA in mice in terms of its acute and sub-acute toxicity complying with regulatory toxicology. Overall, the study demonstrated safety pharmacology of DMCHSA upon intravenous infusion. This is a novel study establishing safety of highly soluble and stable formulation of DMCHSA qualifying it for intravenous administration and further efficacy evaluation in suitable disease models.