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INTERIM ANALYSIS OF CLINICAL TRIALS: SIMULATION STUDIES OF CONDITIONAL POWER UNDER FRACTIONAL BROWNIAN MOTION

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Classical Brownian motion (BM) techniques for statistical monitoring of clinical trials have been widely used. The conditional power (CP) and α-spending function-based boundary crossing probabiliti... Click to show full abstract

Classical Brownian motion (BM) techniques for statistical monitoring of clinical trials have been widely used. The conditional power (CP) and α-spending function-based boundary crossing probabiliti...

Keywords: conditional power; brownian motion; interim analysis; clinical trials

Journal Title: Fractals
Year Published: 2019

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