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A new methodology for the synthesis of a new series of mesotetrakis[aryl]-21H,23H-porphyrin derivatives 5a–5d, 6a–6c, 7 and 8 is presented. Structures of new compounds were established based on both elemental… Click to show full abstract
A new methodology for the synthesis of a new series of mesotetrakis[aryl]-21H,23H-porphyrin derivatives 5a–5d, 6a–6c, 7 and 8 is presented. Structures of new compounds were established based on both elemental and spectral data. Cytotoxicity activity of the newly synthesized compounds was investigated against two human cell lines MCF-7 and HepG2. Molecular docking was performed to investigate the binding between the most active porphyrin derivatives and Bcl-2 molecular biomarkers in HepG2 cells.
Keywords:
synthesis;
docking new;
new approach;
activity;
synthesis docking;
approach synthesis
Journal Title: Journal of Porphyrins and Phthalocyanines
Year Published: 2019
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Journal Title: Journal of Porphyrins and Phthalocyanines
Year Published: 2019
Link to full text (if available)
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recommendations!