LAUSR

CONTEXT Male military personnel conducting strenuous operations experience reduced testosterone, muscle mass, and performance. Pharmacological restoration of normal testosterone may attenuate performance decrements by mitigating muscle loss. Previously, administering testosterone enanthate (200 mg/week) during energy deficit prompted supraphysiological testosterone concentrations and lean mass gain without preventing isokinetic/isometric deterioration. Whether administering a practical dose of testosterone protects muscle and performance during strenuous operations is undetermined. OBJECTIVE Test the effects of a single dose of testosterone on body composition and military-relevant physical performance during a simulated operation. METHODS After a 7-day baseline phase (P1), 32 males (mean±SD; 77.1±12.3 kg, 26.5±4.4 years) received a single dose of either testosterone undecanoate (750 mg; TEST) or placebo (PLA) before a 20-day simulated military operation (P2), followed by a 23-day recovery (P3). Assessments included body composition and physical performance at the end of each phase and circulating endocrine biomarkers throughout the study. RESULTS Total and free testosterone concentrations in TEST were greater than PLA throughout most of P2 (p<0.05), but returned to P1 values during P3. Fat-free mass (FFM) was maintained from P1 to P2 in TEST (mean±SE; 0.41±0.65 kg, p=0.53), but decreased in PLA (-1.85±0.69 kg, p=0.01) and recovered in P3. Regardless of treatment, total body mass and fat mass decreased from P1 to P2 (p<0.05), but did not fully recover by P3. Physical performance decreased during P2 (p<0.05) and recovered by P3, regardless of treatment. CONCLUSIONS Administering testosterone undecanoate before a simulated military operation protected FFM but did not prevent decrements in physical performance.