LAUSR

The effects of low load resistance training with blood flow restriction (BFR) on hypertrophy of type I/II myofibers remains unclear, especially in females. The purpose of the present study is to examine changes in type I/II myofiber cross-sectional area (fCSA) and muscle CSA (mCSA) of the vastus lateralis (VL) pre- to post-6 weeks of high load resistance training (HL, n=15, 8 females) and low load resistance training with BFR (n=16, 8 females). Mixed-effects models were used to analyze fCSA with group (HL, BFR), sex (M, F), fiber type (I, II), and time (Pre-, Post-) included as factors. mCSA increased pre- to post-training (p<0.001, d=0.91) and was greater in males compared to females (p<0.001, d=2.26). Type II fCSA increased pre- to post-HL (p<0.05, d=0.46) and was greater in males compared to females (p<0.05, d=0.78). There were no significant increases in fCSA pre- to post-BFR for either fiber type or sex. Cohen's d, however, revealed moderate effect sizes in type I and II fCSA for males (d=0.59 & 0.67), although this did not hold true for females (d=0.29 & 0.34). Conversely, the increase in type II fCSA was greater for females than males following HL. In conclusion, low load resistance training with BFR may not promote myofiber hypertrophy to the level of HL resistance training, and similar responses were generally observed for males and females. In contrast, comparable effect sizes for mCSA and 1RM between groups suggest that BFR could play a role in a resistance training program.