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Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but… Click to show full abstract
Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature, and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.
Keywords:
mechanobiology vascular;
physiology;
vascular remodeling;
remodeling aging;
aging lung;
lung
Journal Title: Physiology
Year Published: 2021
Link to full text (if available)
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Journal Title: Physiology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!