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Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

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Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS) following intracerebral hemorrhage (ICH) and plays an important role in secondary brain injury caused by the inflammatory… Click to show full abstract

Oxidative stress (OS) is induced by the accumulation of reactive oxygen species (ROS) following intracerebral hemorrhage (ICH) and plays an important role in secondary brain injury caused by the inflammatory response, apoptosis, autophagy, and blood-brain barrier (BBB) disruption. This review summarizes the current state of knowledge regarding the pathogenic mechanisms of brain injury after ICH, markers for detecting OS, and therapeutic strategies that target OS to mitigate brain injury.

Keywords: following intracerebral; brain; intracerebral hemorrhage; oxidative stress

Journal Title: Oxidative Medicine and Cellular Longevity
Year Published: 2021

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