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HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression

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Methods We performed qRT-PCR, cell cycle assay, cell migration, and mouse transplantation model analysis in our experiments. It has been clarified that HuR and microRNAs (miRNAs) have important interplays in… Click to show full abstract

Methods We performed qRT-PCR, cell cycle assay, cell migration, and mouse transplantation model analysis in our experiments. It has been clarified that HuR and microRNAs (miRNAs) have important interplays in the regulation of tumor progression. Results This study found microRNA-133b (miR-133b), as a HuR-sponged miRNA in GC cells. Downregulation of HuR can promote the expression of miR-133b and further affect the downstream cyclin CDC5L. The expressions of miR-133b were slightly lower in GC tissues than adjacent normal tissues. Conclusion Our studies suggest that HuR and miR-133b are involved in the development and pathological process of GC cells.

Keywords: expression; hur promotes; promotes progression; mir 133b; progression gastric; hur

Journal Title: Disease Markers
Year Published: 2022

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