LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Animal Models and Pathogenesis of Ulcerative Colitis

Photo from wikipedia

Background Ulcerative colitis (UC) is a kind of inflammatory bowel disease which is needed to be predicted. Objective To analyze various animal models of UC conditions and summarizes the animal… Click to show full abstract

Background Ulcerative colitis (UC) is a kind of inflammatory bowel disease which is needed to be predicted. Objective To analyze various animal models of UC conditions and summarizes the animal selection, model progression, and pathogenic mechanisms of UC animal models. Methods We surveyed the research papers published in PubMed, Google Scholar, Baidu Scholar, CNKI, SciFinder, and Web of Science in the past 5 years and discussed the experimental animals, modeling methods, and pathogenic mechanisms. Results In the selection of experimental animals, rats are considered the best experimental animals. The mainstream modeling methods can be categorized into the chemical stimulation method, immune stimulation method, and compound method, among which the compound method is the most successful. In the study of the pathogenesis of UC, the pathogenesis of UC is due to various pathogenic factors, such as nitric oxide (NO), prostaglandins (PG), proinflammatory factors (IL, TNF-α), and intestinal flora. Conclusion The method of building an animal model of UC is well-established, providing a more targeted selection of animal models for future related experiments.

Keywords: animal models; method; ulcerative colitis; experimental animals; models pathogenesis

Journal Title: Computational and Mathematical Methods in Medicine
Year Published: 2022

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.