LAUSR

Objectives: Both areca nut and Fuzhuan brick tea have shown the potential to help people lose weight. This paper aims to study the effects of adding 20% (w/w) concentration of areca nut (FTA) in Fu brick tea on the serum and liver lipid metabolism of mice to offer new ideas for the treatment of obesity and hyperlipidemia and to provide a theoretical basis for the safe use and future development of the areca nut products.Results: FTA may have reduced weight; prevented fat accumulation; attenuated the increase in LDL‐C, FFA, GLU, INS, LEP, TC, TG, and MDA; and alleviated the reduction in HDL‐C, TBA, SOD, and GSH. Furthermore, according to GO functional enrichment analysis, FTA may have also reversed the negative effects of a high‐fat diet by upregulating the expression of FABP2, ACSL1, ACSL5, PLIN2, PLIN5, and ACOX1.Conclusion: FTA may favorably reverse the effects of a high‐fat diet on physiological indices, blood indices, and hepatic lipid metabolism. Furthermore, at the genetic level, FTA may suppress body fat accumulation, improve lipid metabolism, relieve insulin resistance, and reduce chronic metabolic disease incidence via the PPAR signaling pathway.