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EGFR-Dependent Regulated Intramembrane Proteolysis of EpCAM-Letter.

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Hsu and colleagues reported on EGF/EGFR–triggered activation of regulated intramembrane proteolysis (RIP) of EpCAM that induces an EMT phenotype ([1][1]). This finding is of utmost interest, as it might explain… Click to show full abstract

Hsu and colleagues reported on EGF/EGFR–triggered activation of regulated intramembrane proteolysis (RIP) of EpCAM that induces an EMT phenotype ([1][1]). This finding is of utmost interest, as it might explain contradicting effects of EpCAM on adhesion, proliferation, and invasion and shed light

Keywords: egfr dependent; dependent regulated; intramembrane proteolysis; epcam; regulated intramembrane

Journal Title: Cancer research
Year Published: 2017

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