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SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy

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The identification of the SETDB1-mediated suppression of radiotherapy-induced viral mimicry reveals SETDB1 inhibition as a potential approach to sensitize tumors to radiotherapy by enhancing the type I interferon response. Click to show full abstract

The identification of the SETDB1-mediated suppression of radiotherapy-induced viral mimicry reveals SETDB1 inhibition as a potential approach to sensitize tumors to radiotherapy by enhancing the type I interferon response.

Keywords: restrains endogenous; setdb1; setdb1 restrains; endogenous retrovirus; radiotherapy; retrovirus expression

Journal Title: Cancer Research
Year Published: 2022

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