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The mechanistic target of rapamycin (mTOR) is a master regulator of cell growth that controls cell homeostasis in response to nutrients, growth factors, and other environmental cues. Recent studies have… Click to show full abstract
The mechanistic target of rapamycin (mTOR) is a master regulator of cell growth that controls cell homeostasis in response to nutrients, growth factors, and other environmental cues. Recent studies have emphasized the importance of lysosomes as a hub for nutrient sensing, especially amino acid sensing by mTORC1. This review highlights recent advances in understanding the amino acid-mTORC1 signaling axis and the role of mTORC1 in cancer.
Keywords:
acid sensing;
role mtorc1;
mtorc1;
central role;
amino acid
Journal Title: Cancer research
Year Published: 2022
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Journal Title: Cancer research
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!