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Mutations in BRAF outside of the 600 codons (BRAF non- V600) occur across cancer types, including in 3% to 5% of melanomas. The optimal treatment strategies are not clear but… Click to show full abstract
Mutations in BRAF outside of the 600 codons (BRAF non- V600) occur across cancer types, including in 3% to 5% of melanomas. The optimal treatment strategies are not clear but based on preclinical studies could include MEK inhibitors. Combining BRAF and MEK inhibitors in this population may provide additional benefit. See related article by Dankner et al., p. 6483
Keywords:
braf mutant;
class matters;
sensitivity braf;
mutant melanoma;
matters sensitivity;
braf
Journal Title: Clinical Cancer Research
Year Published: 2018
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Journal Title: Clinical Cancer Research
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!