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Is GPNMB the Achilles' Heel of Mo-MDSC While Marking Their Suppressive Activity?

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Glycoprotein nonmetastatic B/DC-Hil/Osteoactivin on myeloid-derived suppressor cells impairs T lymphocytes through the binding of Syndecan-4, delineating a new checkpoint pair to be targeted perhaps in combination with PD-1/PD-L1 blockage. See… Click to show full abstract

Glycoprotein nonmetastatic B/DC-Hil/Osteoactivin on myeloid-derived suppressor cells impairs T lymphocytes through the binding of Syndecan-4, delineating a new checkpoint pair to be targeted perhaps in combination with PD-1/PD-L1 blockage. See related article by Kobayashi et al., p. 828

Keywords: gpnmb achilles; suppressive activity; heel mdsc; achilles heel; marking suppressive; mdsc marking

Journal Title: Clinical Cancer Research
Year Published: 2018

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