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Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound… Click to show full abstract
Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound implications in protein trafficking and antigen presentation and suggest a novel way to enhance the potency of existing anticancer agents. See related article by Jaeger et al., p. 6392
Keywords:
low level;
inhibition hsp90;
level inhibition;
level
Journal Title: Clinical Cancer Research
Year Published: 2019
Link to full text (if available)
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Journal Title: Clinical Cancer Research
Year Published: 2019
Link to full text (if available)
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recommendations!