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ctDNA in Gastric and Gastroesophageal Cancer: Prognostic, Predictive, or Preliminary?

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In gastric and gastroesophageal adenocarcinoma, circulating tumor DNA identifies molecular drivers missed using routine tumor biopsy, can refine patient selection for targeted therapy, and may be prognostic following surgical resection.… Click to show full abstract

In gastric and gastroesophageal adenocarcinoma, circulating tumor DNA identifies molecular drivers missed using routine tumor biopsy, can refine patient selection for targeted therapy, and may be prognostic following surgical resection. However, lack of standardization could impede adoption of this technology as a clinically useful tool; prospective validation in clinical trials is required. See related article by Maron et al., p. 7098

Keywords: ctdna gastric; gastric gastroesophageal; cancer prognostic; gastroesophageal; gastroesophageal cancer

Journal Title: Clinical Cancer Research
Year Published: 2019

Link to full text (if available)


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