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TNFα Blockade in Checkpoint Inhibition: The Good, the Bad, or the Ugly?

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The impact on survival of steroids and TNFα blockade to treat immune-related toxicity from checkpoint blockade with ipilimumab, nivolumab/pembrolizumab, or combined ipilimumab and nivolumab was assessed using data from a… Click to show full abstract

The impact on survival of steroids and TNFα blockade to treat immune-related toxicity from checkpoint blockade with ipilimumab, nivolumab/pembrolizumab, or combined ipilimumab and nivolumab was assessed using data from a large national database. Using steroids was associated with better survival than the use of TNFα-blocking antibodies such as infliximab. See related article by Verheijden et al., p. 2268

Keywords: tnf blockade; blockade checkpoint; good bad; checkpoint inhibition; bad ugly; inhibition good

Journal Title: Clinical Cancer Research
Year Published: 2020

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