LAUSR

Despite decades of advancements, cancer remains the second leading cause of mortality in the United States with an estimated 1.7 million new cases and over 600,000 deaths predicted for 2016, indicating a clear need for more effective chemotherapeutic and chemopreventive agents. While natural products derived from plants have served as an abundant source of anticancer agents, it is predicted that less than 2 percent of the plant species with medicinal value have been investigated. Muscadine grape (Vitis rotundifolia) skin and/or seed extracts are a popular nutraceutical supplement due to the high anti-oxidant, anti-inflammatory, and anti-proliferative effects of a distinct phytochemical composition of polyphenols and proanthocyanidins. The current study examines the effects of a proprietary muscadine grape extract formulation (MGE; Piedmont Research & Development Corp.) on the proliferation of prostate cancer cells and tumors. MGE inhibited the growth of human LnCaP prostate cancer cells, in both a time- and dose-dependent manner, as quantified using an IncuCyte Zoom Imaging system. Cell growth was reduced by 36.8% after a 5-day treatment with 20 µg/mL MGE compared to untreated cells (n = 6, p Citation Format: Patricia E. Gallagher, E. Ann Tallant. Inhibition of prostate tumor growth by an extract from the muscadine grape [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1591. doi:10.1158/1538-7445.AM2017-1591