LAUSR

Retinol, one of the most biologically active forms of vitamin A, influences many biologic pathways potentially related to cancer. However, results of observational studies of serum retinol and cancer risk have been mixed. We prospectively examined serum retinol and risk of overall and site-specific cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a randomized, double-blind, placebo controlled trial of α-tocopherol (AT) and β-carotene (BC) supplementation conducted in male smokers in southwestern Finland. At enrollment, overnight fasting blood samples were collected and stored at -70°C protected from light. Serum retinol concentration was measured for all 29,133 participants using reverse-phase high performance liquid chromatography. 10,798 cancer cases occurred through 12/31/2012. Cox proportional hazards models were used to estimate the prospective association between quintiles of baseline serum retinol and overall and site-specific cancer incidence. Known or hypothesized risk factors for cancer were included in the multivariable model (AT and BC supplementation group, cigarettes smoked/day, years smoked, age, BMI, alcohol intake, and serum AT, BC, and cholesterol). Stratified analyses for all subgroups of the covariates (by category or by medians for continuous variables) and follow-up time to diagnosis ( Citation Format: Manila Hada, Alison Mondul, Stephanie Weinstein, Demetrius Albanes. Serum retinol and risk of overall and site-specific cancer in the Alpha Tocopherol, Beta-Carotene Cancer Prevention Study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2275. doi:10.1158/1538-7445.AM2017-2275