LAUSR

Fibroblast Growth Factor Receptor 4 (FGFR4) is a receptor tyrosine kinase that is highly expressed in rhabdomyosarcoma (RMS), an aggressive soft tissue sarcoma originating from skeletal muscle in children and adolescent young adults. FGFR4 is expressed during development in myoblasts, but not in terminally differentiated skeletal muscle. Of note, FGFR4 is directly induced by the chimeric fusion oncogene PAX3-FOXO1 found in the most aggressive fusion-positive RMS and is mutationally activated in approximately 10-13% of the remaining fusion-negative RMS. High FGFR4 expression is associated with adverse outcome and is a driver oncogene in RMS. Metastatic RMS has a dismal outcome in the clinic with Citation Format: Martin Skarzynski, Nitya Shivaprasad, Baskar Subramanian, David Azorsa, Zhongyu Zhu, Dimiter Dimitrov, Javed Khan. Antibody-based targeting of the cell surface receptor tyrosine kinase FGFR4 in rhabdomyosarcoma and other cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 693. doi:10.1158/1538-7445.AM2017-693