LAUSR

Introduction: Five-year survival of metastatic renal cell carcinoma (mRCC) patients is Methods: Expression of SLC (13A3, 22A6, 47A1, 5A10) and SIRT 1-7 transcript levels was evaluated in a TCGA RCC-dataset (n=604 patients). 13A3 expression was measured by quantitative RT-PCR (qPCR) in matched normal and RCC specimens from 53 patients. Biomarker levels were correlated with clinical outcome, using Mann-Whitney test. RCC cells stably-expressing SLC13A3, were examined for proliferation and cell cycle under normoxia and hypoxia. Results: In the TCGA dataset, SIRT4, SIRT5, SLC22A6, SLC5A10, and SLC47A1 downregulation and SIRT2, SIRT6 and SIRT7 upregulation correlated with higher tumor-stage and metastasis (P Conclusion: SLC/SIRT family members are potential prognostic biomarkers for RCC. This first study on SLC13A3 reveals that it is a potential tumor suppressor and its downregulation in RCC tissues correlates with metastasis and racial disparity. Citation Format: Andre R. Jordan, Naureen Mullani, Asif Talukder, Vinata B. Lokeshwar. Small solute carrier and sirtuin genes are potential prognostic biomarkers for renal cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 587.