LAUSR

Prostate cancer is the second most frequently diagnosed malignancy among males in many countries. There are critical needs to better understand its etiology and identifying effective biomarkers to improve its early detection. Many proteins are modified by glycans that bind to the proteins, a post-translational modification that are critical for normal physiological processes. Studies have linked dysregulation of glycosylation to several human diseases including prostate cancer. Multiple glycan alterations have been identified to be potentially related to prostate cancer, such as changes to PSA glycosylation, sialylation and core fucosylation, O-GlcNacylation, cryptic and branched N-glyans, as well as galectins and proteoglycans. Limited research, however, has been performed to comprehensively evaluate relationship between N-glycans and prostate cancer. To identify novel N-glycans that are potentially associated with prostate cancer risk, we performed a study using a highly novel and cost-efficient approach. Using genetic variants reported to be associated with plasma N-glycan levels in large genome-wide associations studies as instruments, we evaluated associations between plasma N-glycans and prostate cancer risk, using the inverse variance weighted method (IVW). Data generated from 79,194 prostate cancer cases and 61,112 controls of European ancestry included in PRACTICAL/ELLIPSE consortia were used in this analysis, providing sufficient power for our research question of interest. We observed associations between genetically predicted plasma levels of two N-glycans and prostate cancer risk at P In conclusion, our agnostic analysis does not identify novel N-glycans whose genetically predicted levels in plasma are associated with prostate cancer risk. Further studies are needed to better characterize the relationship between N-glycans and prostate cancer. Citation Format: Tianying Zhao, Jingjing Zhu, Lang Wu. Genetically predicted plasma N-glycans and prostate cancer risk: Analysis of over 140,000 European descendants [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3519.