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Metabolite profiles reflect the integrated impact of the genome and exogenous exposures on the metabolic state and may provide insight into biologic mechanisms contributing to breast cancer development. To better understand this, we explored the association between pre-diagnostic plasma metabolites (N=307) and breast cancer among women in the Nurses9 Health Study. Plasma metabolites were profiled for cases and controls via liquid chromatography tandem mass spectrometry (LC-MS) using samples taken ≥10 years prior to diagnosis (distant, N=939 cases), and Citation Format: Kristen D. Brantley, Oana A. Zeleznik, Rulla Tamimi, Bernard Rosner, Julian Avila-Pacheco, Clary B. Clish, A Heather Eliassen. Circulating plasma metabolites and breast cancer risk [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 745.