LAUSR

Recent evidence suggests that MCF7 cells utilize free fatty acids as a primary energy source by increasing lipase activity in neighboring adipocytes. Research in our lab suggests that lipase activity is increased by cinnamon extract in differentiated 3T3-L1 adipocytes. We hypothesized that since co-cultures between adipocytes and MCF7 cells demonstrated an increase in lipase activity and increased proliferation, cinnamon extract may increase proliferation of MCF7 cells, making cinnamon an important ingredient to avoid in patients with breast cancer. Cells were plated and treated with varying amounts of cinnamon and monitored for proliferation using the MTT assay. Cells consistently, albeit not significantly, showed an increase in proliferation when treated with cinnamon. Additional studies need to be completed in order to confirm these effects and look for significance, although the importance of this finding warrants rapid reporting. Our lab will examine the effects of cinnamon extract at varying concentrations on MCF7 cell proliferation under variable media conditions as well as monitoring the lipase activity in the MCF7 cells. Citation Format: Madison Anderson, Amy Stockert. Effects of cinnamon extracted under acidic conditions on proliferation of MCF7 cells. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4848.