LAUSR

Cancer Predisposition is a complex and multifaceted topic that continues to intrigue researchers and scientists for decades. This thesis delves into the intricate web of factors that contribute to an individual's predisposition to cancer, aiming to unravel the mysteries surrounding this phenomenon. Through a comprehensive review of existing literature and cutting-edge research findings, the paper explores the genetic, environmental, and lifestyle factors that play a crucial role in predisposing individuals to cancer. By examining the interplay between genetic mutations, familial history, and environmental exposures, this study sheds light on the intricate mechanisms underlying cancer predisposition. Furthermore, the thesis investigates the role of epigenetic modifications, immune system dysregulation, and metabolic abnormalities in shaping an individual's susceptibility to cancer. The intricate interactions between these factors and their collective impact on cancer risk are analyzed, providing valuable insights into the underlying causes of cancer predisposition. By synthesizing the latest research findings in the field, this thesis offers a comprehensive overview of the complex nature of cancer predisposition and its multifactorial etiology. Ultimately, this study aims to contribute to our understanding of the intricate interplay between genetics, environment, and lifestyle in shaping an individual's susceptibility to cancer, paving the way for targeted prevention and personalized treatment strategies in the fight against this devastating disease. Citation Format: Peter Oloche O. David. Unraveling the complex interplay of genetic, environmental, and lifestyle factors in cancer predisposition: A comprehensive review and analysis [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pediatric Cancer Research; 2024 Sep 5-8; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl):Abstract nr A028.