LAUSR

Background: Adjuvant chemotherapy may cause alterations in serum lipids in postoperative breast cancer (BC) patients, but the specific alterations caused by different chemotherapy modalities remain unclear. The aim of this study was to investigate the status of serum lipids pre- and post-chemotherapy and to compare lipid level alterations among different chemotherapy modalities. Methods: We retrospectively analysed the lipid profiles of 1934 consecutive postoperative BC patients who received one of the following chemotherapy modalities: doxorubicin and cyclophosphamide followed by paclitaxel (AC-T); epirubicin and cyclophosphamide followed by paclitaxel (EC-T); cyclophosphamide and paclitaxel (TC); and fluorouracil, cyclophosphamide and epirubicin (FEC). Results: The levels of triglycerides (TGs), total cholesterol (TC) and low-density lipoprotein (LDL) were significantly elevated in patients who received chemotherapy (p Citation Format: Tao He, Yunhao Wu, Xinyi Zhang, Jie Chen. Adjuvant chemotherapy-associated lipid changes in breast cancer patients: A retrospective analysis [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P2-14-21.