LAUSR

It is now becoming possible to bring powerful genomic methods to bear on the process of drug discovery. This talk will illustrate 1) the use of the Connectivity Map, a large-scale effort to develop a compendium of gene expression signatures of cellular state; 2) the use of PRISM, a new multiplexed, high-throughput approach to screening cancer cell lines for anticancer activity; and 3) the use of cancer models (cell lines and patient-derived xenografts) in discovery, with particular focus on clonal drift in these models and the impact of that drift on drug sensitivity. Citation Format: Todd Golub. Genomic approaches to drug discovery [abstract]. In: Proceedings of the AACR Conference on Advances in Sarcomas: From Basic Science to Clinical Translation; May 16-19, 2017; Philadelphia, PA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(2_Suppl):Abstract nr IA05.