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For Whom the Bell Tolls? A Toll-Like Receptor 9 Agonist's Journey from Vaccine Adjuvant to Promising Agent in Anti-PD-1-Resistant Melanoma.

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SUMMARY Developing effective therapies in anti-PD-1-resistant melanoma is a key unmet need. The combination of pembrolizumab with the intralesional TLR9 agonist vidutolimod showed promise in this patient population with correlative… Click to show full abstract

SUMMARY Developing effective therapies in anti-PD-1-resistant melanoma is a key unmet need. The combination of pembrolizumab with the intralesional TLR9 agonist vidutolimod showed promise in this patient population with correlative analysis suggesting that patients with a "cold" tumor immune microenvironment may be the best patients to study further. See related article by Ribas et al., p. 2998.

Keywords: tolls toll; resistant melanoma; bell tolls; anti resistant; toll like

Journal Title: Cancer discovery
Year Published: 2021

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