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Extrachromosomal oncogene amplification on extrachromosomal DNA (ecDNA) has emerged as a hallmark of many cancers. In this issue, Yi and colleagues developed a CRISPR-based method for imaging ecDNA in live… Click to show full abstract
Extrachromosomal oncogene amplification on extrachromosomal DNA (ecDNA) has emerged as a hallmark of many cancers. In this issue, Yi and colleagues developed a CRISPR-based method for imaging ecDNA in live cells, termed ecTag. Using ecTag, the authors reveal important features of ecDNA in cancer cells such as their random mitotic segregation and clustering into transcriptionally active hubs after mitosis.See related article by Yi et al., p. 468.
Keywords:
light ecdna;
behavior using;
using crispr;
ecdna behavior;
crispr based;
shedding light
Journal Title: Cancer discovery
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer discovery
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!