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Loss-of-function alterations in LZTR1, a Cullin-3 RING E3 ubiquitin ligase adapter, and impaired ubiquitin-mediated degradation of RAS proteins via mutations in RIT1 drive clonal hematopoietic transformation. Click to show full abstract
Loss-of-function alterations in LZTR1, a Cullin-3 RING E3 ubiquitin ligase adapter, and impaired ubiquitin-mediated degradation of RAS proteins via mutations in RIT1 drive clonal hematopoietic transformation.
Keywords:
hematopoietic transformation;
impaired proteolysis;
ras proteins;
proteolysis noncanonical;
clonal hematopoietic
Journal Title: Cancer Discovery
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer Discovery
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!