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Mutational scanning in base-edited IDH-mutant leukemia cells uncovered recurrent mutations that disable uncompetitive inhibition, which reveals a new class of pathogenic mutations and mechanisms for resistance to IDH-targeting therapies. Click to show full abstract
Mutational scanning in base-edited IDH-mutant leukemia cells uncovered recurrent mutations that disable uncompetitive inhibition, which reveals a new class of pathogenic mutations and mechanisms for resistance to IDH-targeting therapies.
Keywords:
inhibition;
disabling uncompetitive;
uncompetitive inhibition;
inhibition oncogenic;
idh;
resistance
Journal Title: Cancer Discovery
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer Discovery
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!