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PRC2 inactivation in malignant peripheral nerve sheath tumors and melanoma potentiates DNMT1 inhibitor–mediated derepression of retrotransposons, which leads to increased immune pathway signaling and cell death through the double-stranded RNA… Click to show full abstract
PRC2 inactivation in malignant peripheral nerve sheath tumors and melanoma potentiates DNMT1 inhibitor–mediated derepression of retrotransposons, which leads to increased immune pathway signaling and cell death through the double-stranded RNA sensor PKR.
Keywords:
inactivating mutations;
mutations cancer;
enhance cytotoxic;
cancer enhance;
prc2 inactivating;
cancer
Journal Title: Cancer Discovery
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer Discovery
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!