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Mutant NPM1 in leukemia obtains neomorphic activity to hijack active HOXA/B and MEIS1 transcription on chromatin via the association of XPO1 and blocks the histone deacetylase activity associated with myeloid… Click to show full abstract
Mutant NPM1 in leukemia obtains neomorphic activity to hijack active HOXA/B and MEIS1 transcription on chromatin via the association of XPO1 and blocks the histone deacetylase activity associated with myeloid differentiation.
Keywords:
transcriptional hubs;
mutant npm1;
leukemia;
hijacks transcriptional;
npm1 hijacks;
npm1
Journal Title: Cancer Discovery
Year Published: 2022
Link to full text (if available)
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Journal Title: Cancer Discovery
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!