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Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma

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Cancer cell genomic instability correlates with proinflammatory IL6 and IL8 production, VEGF, as well as regulatory T cells and is associated with primary resistance to immunotherapy and antiangiogenics in patients… Click to show full abstract

Cancer cell genomic instability correlates with proinflammatory IL6 and IL8 production, VEGF, as well as regulatory T cells and is associated with primary resistance to immunotherapy and antiangiogenics in patients with advanced mesothelioma.

Keywords: primary resistance; genomic instability; instability protumoral; associated primary

Journal Title: Cancer Discovery
Year Published: 2023

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