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Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

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Combinatorial levels of BCL2 family members in acute myeloid leukemia stem cells are a key denominator of response to BCL2 inhibitor therapy, and flow cytometry–based measurements predict response in patients… Click to show full abstract

Combinatorial levels of BCL2 family members in acute myeloid leukemia stem cells are a key denominator of response to BCL2 inhibitor therapy, and flow cytometry–based measurements predict response in patients both reliably and quickly.

Keywords: myeloid leukemia; bcl2 family; leukemia stem; acute myeloid; response; stem cells

Journal Title: Cancer Discovery
Year Published: 2023

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