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Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology

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Summary: The shift in cancer therapy from broadly cytotoxic agents toward “personalized” treatments that target specific alterations in each patient's tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly.… Click to show full abstract

Summary: The shift in cancer therapy from broadly cytotoxic agents toward “personalized” treatments that target specific alterations in each patient's tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can measure single-cell expression of over 60 proteins in intact tumor sections and hold promise for clinical oncology.

Keywords: oncology; resolved multiplexed; multiplexed protein; moving spatially; spatially resolved; clinical oncology

Journal Title: Cancer Discovery
Year Published: 2023

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